Fig. 2
From: Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer
Summary of the m6A modification mechanism mediated by writers, erasers, and readers. The methyltransferase complex composed of the METTL3-METTL14-WTAP core component and other regulatory cofactors (KIAA1429, RBM15, ZC3H13, and METTL16) catalyses methylation at the N6 adenosine. Moreover, m6A can be reversibly removed by m6A eraser proteins (FTO and ALKBH5). m6A can also be recognized by m6A-binding proteins to affect mRNA fate. YTHDC1 can affect the exportation of m6A-modified mRNA transcripts from the nucleus to the cytoplasm, while METTL3, EIF3, IGF2BP1/2/3, YTHDF1/3, and YTHDC2 can promote the translation of RNA. YTHDC1, HNRNPA2B1, and HNRNPC can promote RNA splicing. IGF2BP1/2/3 can enhance RNA stability, while YTHDF2/3 and YTHDC2 accelerate the decay of RNA