Fig. 4From: Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancerThe upstream region of METTL3 in gastrointestinal cancer. Histone H3K27ac and hypomethylation at the promoter can increase METTL3 mRNA expression. The transcription factor GFI-1 might promote METTL3 mRNA expression. Non-coding RNA ARHGAP5-AS1 and miR-24-2 can promote METTL3 mRNA expression, while miR-4429 can inhibit METTL3 mRNA expressionBack to article page