Table 1 Role of METTL3 in gastrointestinal cancer
From: Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer
Cancer type | Role of METTL3 | Target | Biological function | Mechanism | Upstream | Reader | Ref |
|---|---|---|---|---|---|---|---|
GC | Oncogene | HDGF | Promotes cell proliferation, invasion, and migration, tumor growth, angiogenesis, liver metastasis, glycolysis | Enhance HDGF mRNA stability | H3K27ac | IGF2BP3 | [33] |
Oncogene | LINC00470 | Promotes cell proliferation, invasion, and migration | Interacts with LINC00470 to suppress PTEN stability | No study | YTHDF2 | [34] | |
Oncogene | ZMYM1 | Promotes EMT process and metastasis | Enhance ZMYM1 mRNA stability | No study | ELAVL1 | [35] | |
Oncogene | SEC62 | Promotes cell proliferation and inhibits apoptosis | Enhance SEC62 mRNA stability | MiR-4429 | IGF2BP1 | [36] | |
Oncogene | EMT markers | Promotes cell proliferation, invasion, and migration | Promotes EMT process | Transcription factor GFI- 1 | No study | [37] | |
Oncogene | ARHGAP5-AS1 | Promotes chemoresistance | Stimulates m6A of ARHGAP5 mRNA to enhance ARHGAP5-AS1 stability | ARHGAP5-AS1 | No study | [38] | |
Oncogene | AKT pathway, apoptosis pathway | Promotes cell proliferation, migration, and invasion | Activates AKT and decreases apoptosis pathway | No study | No study | [39] | |
Oncogene | MYC | Promotes cell proliferation, migration, and invasion | Activates MYC | No study | No study | [40] | |
CRC | Oncogene | miR-1246 | Promotes cell migration, invasion and metastasis | Promotes the maturation of pri-miR-1246 | No study | No study | [41] |
Tumor suppressor | p-p38 and p-ERK | Inhibits proliferation, migration, and invasion | Inhibits p-p38 and p-ERK pathway | No study | No study | [42] | |
Oncogene | SOX2 | Promotes self-renewal, stem cell frequency, migration, and tumorigenesis and metastasis | Prevents SOX2 mRNA degradation | No study | IGF2BP2 | [43] | |
| Â | Oncogene | P53 | Acquires multidrug resistance | Promotes pre-mRNA splicing | No study | No study | [44] |
Oncogene | CCNE1 | Promotes cell proliferation | stabilizes CCNE1 mRNA | No study | No study | [45] | |
| Â | Oncogene | HK2 and GLUT1 | Promotes glycolysis and tumorigenesis. | Stabilized HK2 and GLUT1 mRNA | No study | IGF2BP2/3 | [46] |
LC | Oncogene | miR6079 | accelerates progression of liver cancer cells | Promotes miR6079 expression | miR24-2 | No study | [47] |
Oncogene | LINC00958 | Promotes HCC cell proliferation, motility, lipogenesis, and tumor growth, metastasis | Promotes LINC00958 RNA transcript stability | No study | No study | [48] | |
Oncogene | Snail | Promotes HCC migration, invasion and EMT of cancer cells both in vitro and in vivo. | Triggers polysome-mediated translation of Snail mRNA | No study | YTHDF1 | [49] | |
Oncogene | SOCS2 | Promotes HCC proliferation, migration, colony formation, tumorigenicity, and lung metastasis | Reduces SOCS2 mRNA expression | No study | YTHDF2 | [50] | |
Oncogene | mTORC1 | Promotes HCC glycolysis | Increases mTORC1 activity | No study | No study | [51] | |
PC | Oncogene | Unspecific | Promotes proliferation, invasion, and migration | No study | No study | No study | [52] |
Oncogene | miR-25-3p | Promotes tumorigenesis | Promote miR-25 processing and maturation | Hypomethylation | No study | [53] | |
Oncogene | MAPK, ubiquitin, and RNA splicing | Promotes chemo- and radioresistance | Activates MAPK, ubiquitin, and RNA splicing pathway | No study | No study | [54] |