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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Th17 cells inhibit CD8+ T cell migration by systematically downregulating CXCR3 expression via IL-17A/STAT3 in advanced-stage colorectal cancer patients

Fig. 2

Decreased CXCR3 expression on CD8+ T cells in the PB of advanced-stage CRC patients. b PBMCs were isolated from the PB of CRC patients (n = 125) and HDs (n = 50) and analyzed by flow cytometry. Representative dot plots are shown. Data are presented as the percentage of CXCR3+CD8+ T cells in total CD8+ T cells. b, c The percentage of CXCR3+CD8+ T cells in the PBMCs of early-stage, advanced-stage, non-metastasis, and metastasis CRC patients. d The percentage of CXCR3+CD8+ T cells in tumor tissues of early-stage and advanced-stage patients. e The expression of IFN-Ī³-, granzyme-B-, perforin-, and IL-10-producing CD8+ T cells in total CD8+ T cells from PBMCs of CRC patients. The results for gating cells on the CXCR3 negative population are shown in the left panels and for gating on the CXCR3 positive population on the right. Each line represented a different patient.*P < 0.05, ***P < 0.0001

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