Fig. 1From: Emerging agents that target signaling pathways in cancer stem cellsThe mechanism whereby CSCs contribute to tumor recurrence, metastasis, and drug resistance. Traditional treatment methods (such as chemotherapy and radiotherapy) mainly target ordinary cancer cells but ignore the existence of CSCs. CSCs resist traditional therapy methods through various mechanisms, such as activating the signaling pathways involved in stemness and inhibiting cell death-related pathwaysBack to article page