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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Emerging agents that target signaling pathways in cancer stem cells

Fig. 3

The role of iron in lipid peroxidation. Through the Fenton reaction, Fe2+ and hydrogen peroxide produces OH, and AA (arachidonic acid) can produce PE-AA-OOH through ACSL4 (acyl-CoA synthetase long-chain family member 4), LPCAT3 (lysophosphatidylcholine acyltransferase 3), and the complex of PCPB1, Fe2+, and LOXs (lipoxygenases). PE-AA-OOH, through Fe2+ + PE-AA-OOH → Fe3+ + PE-O, Fe3+ + PE-AA-OOH → Fe2+ + PE-OO, and PE-O/PE-OO + HA → PE-OH/PE-OOH + A produces PE-O, PE-OO, and A. OH, PE-O, PE-OO, and A can attack PUFAs (polyunsaturated fatty acids) to cause lipid peroxidation. In addition, GPX4 can inhibit the production of lipid peroxidation through PE-AA-OOH + GSH → GS-SG + PE-AA-OH

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