Fig. 4
From: Emerging agents that target signaling pathways in cancer stem cells
Summary of small-molecule compounds targeting ferroptosis to induce CSC death. Substituted pyrazoles, benzyl isothioureas, and ebselen can target DMT1 to block iron in lysosomes. Salinomycin and ironomycin can accumulate and isolate iron in the lysosome. Iron in lysosomes can produce OH through the Fenton reaction, and lipid peroxidation is also undertaken in the ferroptosis process. All the products can lead to increased permeability in the lysosomal membrane and cell death. Sulfasalazine can inhibit System Xc−. All these compounds can induce ferroptosis and thus kill CSCs