Table 7 Small-molecule compounds regulating multi-signaling pathways to inhibit CSCs
From: Emerging agents that target signaling pathways in cancer stem cells
Name | Target | Mechanism | Type of cancer | Phase | NCT number (starting time)/publication date | Assessment |
|---|---|---|---|---|---|---|
Z-ajoene | Notch, Wnt, and Hh | Inhibits CSC sphere-forming ability | Glioblastoma multiforme | Preclinical | July, 2014 | Without cytotoxic in normal cells [173] |
Poziotinib | Wnt, Notch, and Hh | Decreases ovarian CSC sphere formation ability | Epithelial ovarian cancer | Preclinical | May 21, 2020 | Diarrhea and rash [174] |
6-Shogaol | Notch and autophagy | Inhibits the number of CD44+/CD24− cell subpopulation and decreases sphere-forming ability | Breast cancer | Preclinical | September 10, 2015 | Induces low toxicity in normal cells [175] |