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Table 7 Small-molecule compounds regulating multi-signaling pathways to inhibit CSCs

From: Emerging agents that target signaling pathways in cancer stem cells

Name Target Mechanism Type of cancer Phase NCT number (starting time)/publication date Assessment
Z-ajoene Notch, Wnt, and Hh Inhibits CSC sphere-forming ability Glioblastoma multiforme Preclinical July, 2014 Without cytotoxic in normal cells [173]
Poziotinib Wnt, Notch, and Hh Decreases ovarian CSC sphere formation ability Epithelial ovarian cancer Preclinical May 21, 2020 Diarrhea and rash [174]
6-Shogaol Notch and autophagy Inhibits the number of CD44+/CD24− cell subpopulation and decreases sphere-forming ability Breast cancer Preclinical September 10, 2015 Induces low toxicity in normal cells [175]