Fig. 2

Targeted inhibition of YAP by VP exerts antitumor effects on DLBCL cells. a LY1, LY8, and LY3 cells were incubated with vehicle control or VP at various concentrations for 24, 48, 72, or 96 h. Relative cell proliferation was assessed with CCK-8. b, c Representative dot plots generated by flow cytometry analysis of LY1, LY8, and LY3 cells treated with VP for 24 h are shown. The results of the quantitative analysis are shown as the mean ± SD from at least three independent experiments. *p < 0.05, **p < 0.01. d The protein expression levels of YAP and TEAD were detected in LY1 and LY8 cells treated with VP at different concentrations. e The expression levels of YAP downstream targets were assessed by qRT-PCR. Data are presented as the mean ± SD from three independent experiments. **p < 0.01