Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma

Table 1 Correlation between YAP protein expression and clinicopathologic parameters of the patients

Variables	No. of patients	YAP expression		p value
Variables	No. of patients	Positive	Negative	p value
Age (years)
≤ 60	34	18 (52.9%)	16 (47.1%)	0.787
> 60	26	18 (56.2%)	14 (43.8%)	0.787
Gender
Male	30	19 (63.3%)	11 (36.7%)	0.598
Female	30	17 (56.7%)	13 (43.3%)	0.598
Ann Arbor stage
I or II	20	11 (55%)	9 (45%)	0.576
III or IV	40	25 (62.5%)	15 (37.5%)	0.576
B symptoms
Present	15	13 (86.7%)	2 (13.3%)	0.015*
Absent	45	23 (51.1%)	22 (48.9%)	0.015*
Subtype
GCB	20	14 (70%)	6 (30%)	0.264
Non-GCB	40	22 (55%)	18 (45%)	0.264
Serum LDH
Normal	44	24 (54.5%)	20 (45.5%)	0.153
Elevated	16	12 (75%)	4 (25%)	0.153
Extranodal involvement
Absent	37	18 (48.6%)	19 (51.4%)	0.023*
Present	23	18 (78.3%)	5 (21.7%)	0.023*
IPI score
0–2	37	18 (48.6%)	19 (51.4%)	0.023*
3–5	23	18 (78.3%)	5 (21.7%)	0.023*

GCB germinal center B cell-like, LDH lactate dehydrogenase, IPI International Prognostic Index
*p < 0.05

ISSN: 1756-8722