Fig. 4

Correlation analyses between VISTA and immune regulation across multiple cancers. (a) Correlations between VISTA expression and the immune-related signatures of multiple tumor-infiltrating lymphocytes (TILs) across human cancers. (b) Correlations between VISTA expression and immunoinhibitors. (c) Correlations between VISTA expression and immunostimulators. (d) Correlations between VISTA expression and major histocompatibility complexes (MHCs). (e) Correlations between VISTA expression and chemokines. (f) Correlations between VISTA expression and chemokine receptors. TISIDB was used to generate correlations between expression of VISTA and abundance of TILs or immunomodulators across multiple cancers (TCGA tumor). For each cancer type, the relative abundances of TILs or immunomodulators were inferred by using gene set variation analysis based on gene expression profile. Each correlation between VISTA and a distinct TIL or immunomodulator in an individual cancer type was integrated into the indicated heatmap. Spearman method was used to analyze the pair-wise gene expression correlations, and p value < 0.05 was considered statistically significant