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Table 2 Entry receptors for adenoviruses [37]

From: Oncolytic viruses for cancer immunotherapy

Receptor

Ligand

Reference

Primary receptors

 CXADR (coxsackie-adenovirus receptor)

Ad5 knob (and other groups A, C, D, E, and F)

[38]

 CD46

Ad3 knob (and other groups B and D)

[39]

 Desmoglein-2

Ad3 knob (and other group B)

[40, 41]

 CD80/CD86

Ad3 knob (and other group B)

[33, 37]

Other receptors

 Cellular integrins

Ad capsid (penton base) or Arg-Gly-Asp (RGD) modifications

[42]

 Sialic acid

Ad 37, 8, 19a (group D)

[43]

 MHC-I (major histocompatibility complex class I)

Ad5

[44]

 Vascular adhesion molecule 1 (VCAM-1)

Ad5

[45]

 Heparan sulfate glycosaminoglycans (HS-GAGs)

Ad5

[46]

 Dipalmitoyl phosphatidylcholine (DPPC)

Ad5 hexon

[47]

 Blood coagulation factor F(X)

Ad 5 hexon

[48, 49]