Table 3 Examples of viral modifications in oncolytic adenoviruses

 RGD modification

[59,60,61]

 5/3 chimerism

[62, 63]

 Fully serotype 3, Ad3/Ad11p

[30, 64, 65]

 E1A gene 24-base pair deletion

[61, 66, 67]

 hTERT promoter

[64, 68]

 p53 promoter

[69]

 CEA promoter

[70]

 PSA promoter

[71]

 E2F promotor

[72]

 Cox2l promoter

[73]

 Cytosine deaminase and thymidine kinase

[74]

 Ganciclovir and/or 5-fluorocytosine (5-FC) prodrugs

[75]

 GMCSF

[66, 67, 72, 76, 77]

 CD40L

[78, 79]

 hNIS

[80]

 TNFalpha and interleukin 2

NCT04217473

 CD40L and 41BBL

NCT03225989

 PH20 hyaluronidase

NCT03284268

 Anti-CTLA4

[81]

 IL-12 and decorin

[82]

 OX40L

[83]

 EGFR

[84]

 FR-a

[85]

 FAP

[10]

 CD44v6

[86]