| |
Acute GVHD II–IV
|
Acute GVHD III–IV
|
Chronic GVHD
|
Ext. chronic GVHD
|
|---|
|
HR (95% CI)
|
p value
|
HR (95% CI)
|
p value
|
HR (95% CI)
|
p value
|
HR (95% CI)
|
p value
|
|---|
|
ATG vs PTCY
|
0.98 (0.66–1.46)
|
0.93
|
0.84 (0.42–1.71)
|
0.64
|
1.22 (0.79–1.87)
|
0.37
|
0.64 (0.37–1.09)
|
0.09
|
|
Age (per 10 years)
|
1 (0.91–1.09)
|
0.92
|
1.01 (0.86–1.18)
|
0.92
|
1.06 (0.97–1.16)
|
0.20
|
1.03 (0.89–1.18)
|
0.73
|
|
sec. AML vs de novo
|
1.23 (0.95–1.61)
|
0.12
|
1.26 (0.79–2)
|
0.34
|
1.01 (0.76–1.33)
|
0.96
|
1.62 (1.1–2.39)
|
0.01
|
|
Adverse cytogenetics vs other
|
0.94 (0.74–1.21)
|
0.65
|
1.12 (0.73–1.71)
|
0.60
|
0.73 (0.56–0.96)
|
0.03
|
0.61 (0.39–0.95)
|
0.03
|
|
Female donor-male recipient vs other
|
1.27 (0.96–1.68)
|
0.10
|
1.67 (1.05–2.66)
|
0.03
|
1.07 (0.79–1.45)
|
0.65
|
1.05 (0.66–1.67)
|
0.83
|
|
RIC vs MAC
|
0.79 (0.62–1)
|
0.046
|
0.89 (0.59–1.36)
|
0.60
|
0.97 (0.76–1.23)
|
0.79
|
0.78 (0.54–1.14)
|
0.20
|
|
KPS ≥ 90
|
0.83 (0.65–1.06)
|
0.13
|
0.64 (0.42–0.97)
|
0.03
|
0.91 (0.71–1.17)
|
0.45
|
0.92 (0.63–1.34)
|
0.67
|
|
Patient CMV positivity
|
1.05 (0.85–1.31)
|
0.64
|
1.01 (0.68–1.48)
|
0.98
|
1.28 (1.03–1.6)
|
0.03
|
1.05 (0.75–1.47)
|
0.77
|
|
Donor CMV positivity
|
1 (0.81–1.23)
|
0.99
|
1.06 (0.73–1.53)
|
0.77
|
0.97 (0.79–1.2)
|
0.80
|
1.32 (0.96–1.82)
|
0.09
|
|
Year of transplantation
|
1.01 (0.96–1.06)
|
0.75
|
1.03 (0.94–1.12)
|
0.57
|
1 (0.95–1.05)
|
0.94
|
1.07 (0.99–1.16)
|
0.09
|
|
PBSC vs BM
|
1.05 (0.75–1.47)
|
0.77
|
1.1 (0.6–2)
|
0.76
|
1.1 (0.78–1.55)
|
0.59
|
1.37 (0.79–2.4)
|
0.26
|
- Abbreviations: aGVHD acute graft-versus-host disease, AML acute myeloid leukemia, ATG antithymocyte globulin, BM bone marrow, CI confidence interval, CMV cytomegalovirus, cGVHD chronic graft-versus-host disease, Ext extensive, HR hazard ratio, KPS Karnofsky Performance Status, MAC myeloablative conditioning regimen, PBSC peripheral blood stem cells, PTCY post-transplantation cyclophosphamide, RIC reduced intensity conditioning regimen, sec. AML secondary acute myeloid leukemia
