Fig. 10

HUR, PTPB, or other RNA binding proteins enhance the stabilization of BCL2, MCL1, c-myc, cyclin E1, BLxL, and ZEB1 PTEN-related mRNAs by binding to the ARE sequence elements of mRNA in 3′UTR, thereby increasing the expression of cancer-related proteins and promoting tumor angiogenesis, migration, invasion and drug resistance