Fig. 6

RBP post-translational modifications (PTMs) (acetylation, phosphorylation, methylation, and ubiquitination) are involved in important biological processes. Different PTMs regulate the abundance of RBP, subcellular localization, and different protein kinases and signal transduction pathways. Abnormal PTM promotes carcinogenesis, apoptosis, tumorigenesis and cancer progression by changing the binding ability of IGF2BPs to mRNA, and regulating the protein activity, stability, and localization of hnRNPE1, RBM15 and Sam68