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Fig. 8 | Journal of Hematology & Oncology

Fig. 8

From: RNA-binding proteins in tumor progression

Fig. 8

Alternative splicing contributes to protein diversity and mRNA stability. Abnormal or erroneous splicing of RBPs is one of the causes of cancer. Some RBPs can form complexes with core proteins and combine with splicing, increase or decrease the activity of spliceosomes and jointly control the splicing of tumor cell molecules. SF3B1, hnRNP, and SR proteins are selective splicing regulators. They recognize spliceosomes by binding to spliceosomes, which in turn regulates splicing. Abnormalities in alternative splicing regulators are often associated with tumorigenesis

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