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Table 2 Small molecule inhibitors targeting RBPs

From: RNA-binding proteins in tumor progression

Inhibitor

Structure

Research status and clinical trials

Type of tumor

RBP

reference

1632

pre-clinical

Hepatocellular carcinoma

LIN8

[224]

VPC-80051

pre-clinical

Castration-Resistant Prostate Cancer

hnRNPA1

[225]

L-norleucine

pre-clinical

breast cancer

hnRNPA2/B1

[226]

CMLD-2

pre-clinical

colon cancer

HuR

[227]

Resveratrol

Phase II

Melanoma

RBFox2

[94]

MS-444–

pre-clinical

Colorectal Cancer

HuR

[228]

C1632

pre-clinical

Multiple tumors

LIN8

[51]

BTYNB

pre-clinical

Melanoma and Ovarian Cancer

IMP1

[229]