Fig. 2

Coagulation independent mechanisms of TF-mediated signaling. a flTF:FVIIa can proteolytically cleave PAR2, resulting in the phosphorylation of flTF’s cytoplasmic domain and the recruitment of ABP-280. flTF:FVIIa-mediated cleavage of PAR2 can also promote PAR1/PAR2 heterodimer signaling, when the cleaved tethered ligand binds to adjacent PARs. b flTF:FVIIa:FXa can proteolytically cleave both PAR1 and PAR2. c Binding of flTF:FVIIa to integrins causes their conformation to switch to a high affinity state. d asTF can bind to integrins independent of FVII, causing a conformation switch. e flTF:FVIIa induces transaction of RTKs in a PAR2- and Src-dependent manner. f flTF:FVIIa proteolytically cleaves both EphB2 and EphA2, which then can signal through ephrins