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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

Fig. 1

DNA methylation differs by myeloma subgroup. (a) The median DNA methylation level of the top 5% differentially methylated regions (DMRs) of MM subgroups, compared to control (p<0.001), depicted as boxplots with interquartile range between 25% and 75% across the promoters (n=1,282), gene body (n=6,594) and intergenic regions (n=5,050). (b) Unsupervised hierarchical clustering with the top 5% most variable DMRs (n=12,931) showed distinct methylation pattern among the NDMM subgroups.

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