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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

Fig. 3

DNA methylation and histone modification profile of DSG2 and TEAD1 in the t(4;14) subgroup. (a) DNA methylation distribution along the DMRs (p<0.05) at the promoter (up to 5 kb upstream of the TSS) and gene body of the DSG2 transcript ENST00000261590.12. (b) Observed enrichment of activating histone marks, such as H3K4me1, H3K4me3 or H3K27ac at the promoter and H3K36me3 at the gene body of DSG2 in a t(4;14) cell line. (c) DNA methylation distribution along the DMRs (p<0.05) of the TEAD1 transcript ENST00000527575.5. (d) Observed enrichment of activating histones as the major marks, overlapped with TEAD1 DMRs.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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