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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

Fig. 4

DNA methylation and histone modification profile of RFTN1 and SORT1 in the t(11;14) subgroup. (a) DNA methylation distribution along the DMRs (p<0.05) at the promoter (up to 5 kb upstream to the TSS) and gene body of the RFTN1 transcript ENST00000334133.8. (b) Observed enrichment of repressive H3K27me3, overlapped with hypomethylated DMRs at the gene-body. (c) DNA methylation distribution along the DMRs (p<0.05) of the SORT1 transcript ENST00000256637.7. (d) Observed enrichment of activating histones such as the H3K36me3, overlapped with SORT1 hypermethylated DMRs at the gene body. Histone marks were obtained from a t(11;14) cell line.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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