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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

Fig. 6

DNA methylation and histone modification profile of NUAK1 and LCP2 in the t(14;16) and t(14;20) subgroups. (a) DNA methylation distribution along the DMRs (p<0.05) at the promoter (up to 5 kb upstream to the TSS) and gene body of the NUAK1 transcript ENST00000261402.6. (b) Observed enrichment of activating H3K4me1, H3K4me3 or H3K27ac marks, overlapped with hypomethylated DMRs and H3K36me3 marks overlapped with hypermethylated DMRs at the gene body of NUAK1 in a t(14;16) cell line. (c) DNA methylation distribution along the DMRs (p<0.05) of the LCP2 transcript ENST00000392050.2. (d) Observed enrichment of several activating histones marks including H3K36me3, H3K27ac, or H3K4me1, overlapped with hypermethylaated DMRs at the gene body.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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