Super-enhancer control of gene-expression in MM. Overlapping of super-enhancer (SE)-CTCF loops to the hypomethylated DMRs of the over-expressed (log2 scale) GEMs in t(14;16). (a) ARID5A is 5.74-fold overexpressed, while (b) SMAD7 is 4.44-fold over-expressed and are predicted to be under control of a SE-CTCF loop. The surrounding genes do not show over-expression. (c) An over-expressed gene cassette containing LITAF (2.94-fold increase), the GEM, SNN (5.6-fold increase), TXNDC11 (2.1-fold increase), and ZC3H7A (2.55-fold increase), spanning a 50 kb region or (d) another gene cassette containing the GEM PLA2G15 (4.11-fold increase), SLC7A6 (4.28- fold increase), and PRMT7 (6.82-fold increase), spanning over 20 kb region were identified in the t(14;16) subgroup. Red arrows show the putative boundaries of the SE-CTCF loops.