Skip to main content
Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Correction to: The design and development of covalent protein-protein interaction inhibitors for cancer treatment

Fig. 2

The crystal structure of three different classes of PPIs [2]. A) Linear sequences comprise primary peptide epitopes (e.g. LM of DNA polymerase III bound to the binding pocket of the SC (PDB: 3D1F)); B) the secondary structure of epitopes binds as a single unit. e.g. an α-helix (NusB-NusE PPI (PDB: 3R2C)); and C) in tertiary structural epitopes, the binding interface is not continuous and both sides of PPI interface are needed (e.g. IL-2/IL-2Ra PPI (PDB 1Z92))

Back to article page