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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: A single-cell survey of cellular hierarchy in acute myeloid leukemia

Fig. 3

Characterizing the single-cell gene expression patterns of AML progenitor cell cluster. a Volcano plot of DEGs between progenitor cells (HSPCs and AML progenitor cells) and myeloid cells. Yellow represents the common genes shared by both HSPCs and AML progenitor cells. Gray represents the unique genes in HSPCs or AML progenitor cells. Orange represents the common ribosomal protein (RP) genes shared by both HSPCs and AML progenitor cells. The dots on the right represent the higher expressed genes in progenitor cells, and those on the left represent lower. b Metascape GO analysis for viewing top enrichment terms in AML progenitor cells. Color shows the p value. c Heat map of top DEGs among HSPCs, AML progenitor cells, and myeloid cells. Cell type and individual are indicated by the colored bars. Individual includes the AML patients and HSPC donors. dg Violin plots of DEGs among HSPCs, AML progenitor cells, and myeloid cells. The genes are related to hematopoietic development (d), primitive state (e), AML (f), and other solid tumors (g) in previous studies. h VIPER plot of activated (red) and repressed (blue) TFs in AML progenitor cells. The gene expression signature is rank-sorted from the one most downregulated to the one most upregulated in the AML progenitor cells vs. HSPCs. The column on the right shows the activity level

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