Fig. 4

Intratumoral heterogeneity in AML progenitor cells predicts prognosis. a Subdivision t-SNE analysis of AML progenitor cells. Sixteen clusters are classified into four groups and are labeled in different colors and numbers. b Relative proportion analysis of four cell groups in a. Cells of different FAB subtypes are labeled in different colors. c Metascape KEGG pathway analysis for viewing enrichment terms in 16 clusters. Color shows the p value. d Visualization of the network with the genes of top weighted connectivity in the RP gene module. The circles represent the RP genes, while the colors show the genes in different clusters. e Metascape GO analysis for viewing top enrichment terms in the RP gene module. Color shows the p value. The terms in blue are associated with ribosome biogenesis, and in red are tumor-related. f Pie charts displaying cell distribution of AML progenitor cells of 16 clusters belonging to four cell groups. The patient ID is on the top of each chart. The subtype is on the bottom