Fig. 7

AML target searching based on the HCL. a Feature plots of genes in AML map and HCL. The left panel is the AML map and the right is HCL. Gene expression levels are indicated by blue and yellow. b Correlation networks of the top 10 highly expressed genes and their most relevant genes in AML. The top expressed genes are the core genes in blue. The most relevant genes are in green and purple (RPs). c The top expressed AML genes and their most relevant protein-coding genes in AML progenitor cluster. d Feature plots of MYB, CCNA1, and RAB37 in the AML map and the HCL. The left panel is AML map and the right is HCL. Gene expression levels are indicated by blue and yellow. e The interacting gene analysis using pathway commons. The blue, red, and yellow lines represent the binding, expression-controlled, and state change-controlled (modification) genes, respectively