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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21

Fig. 2

ETV4 expression induces prostatic intraepithelial neoplasia in old mice and increases cell proliferation in prostate. Prostate of wild-type (WT) mice (a) and ETV4 transgenic mice from lines A (b) and B (c) at 11 months (hematoxylin and eosin, magnification × 200). Mouse prostatic intraepithelial neoplasia (mPIN) are indicated by arrowheads in b and c. A minority of cells displayed macronuclei (arrowhead in d) or prominent nucleoli (arrows in d). mPIN foci showed loss of p63-positive basal cells (arrows in e). In rare instances, epithelial cells have cribriform or tufting patterns and exhibited increasingly severe nuclear pleomorphism and hyperchromasia (f). g Cell proliferation analysis by Ki67 staining in the anterior prostate of 5-month-old wild-type (left panel) and ETV4 mice (right panel). Arrows indicate proliferating cells. h Bar diagram of the frequency of Ki67-positive cells in the 3 prostate lobes from 7 mice. Average and standard error values are shown. *P ≤ 0.05

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