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Table 2 Combination therapeutics based on EPHA2 targeting

From: Targeting EphA2 in cancer

Drug Cancer type Effects in vitro Effects in vivo Ref.
ALW-II-41-27 + WW437 Breast cancer Inhibit cell viability and migration - [87]
ALW-II-41-27 + cetuximab CRC Inhibit cell growth, induce apoptosis and cell cycle arrest, revert resistance to cetuximab Inhibit tumor growth [27]
siRNA+ cisplatin/etoposide/minustine hydrochloride Glioma Induce cytotoxicity - [86]
UniPR1331 + bevacizumab Glioblastoma Inhibit tumor growth [63]
DS-8895a + cisplatin Gastric cancer Inhibit tumor growth [56]
EphA2-ILs-DTXp + PD-1 inhibitors Breast cancer (mouse) Inhibit tumor growth [76]