Fig. 2

Crosstalk between necroptosis and antitumor immunity. Two strategies have been reported to trigger antitumor immunity through necroptosis. (1) Vaccination with necroptotic tumor cells: DAMPs released from tumor cells undergoing necroptosis promote the maturation of BMDCs, cross-priming of effector T cells, and subsequent cytotoxic effects. Excessive IFN-γ production is observed during this process, likely representing another anticancer approach used by CD8+ T cells. (2) Vaccination with fibroblasts: necroptotic cells release NF-κB-derived signals, further leading to DC activation, increased antigen loading, and robust CD8+ T cell-mediated tumor control. In this context, DAMPs do not appear to be involved in the activation of antitumor immunity. Tumor clearance is increased by the concomitant administration of PD1 inhibitors