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Table 1 Summary of clinically approved drugs that may induce ferroptosis, necroptosis, and pyroptosis in cancers and their effects on antitumor immunity

From: Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Drug name Daily use Target Effect on tumor cell death References Effect on antitumor immunity References
Sulfasalazine Anti-inflammatory drug System Xc- Ferroptosis induction [121] Unknown  
Glutamate Nutrient System Xc- Ferroptosis induction [59] Increased immune suppression [122]
Sorafenib Anticancer drug System Xc- Ferroptosis/necroptosis induction [123] Null effect on antitumor immunity [124]
Cisplatin Anticancer drug GSH/GSDME Ferroptosis/pyroptosis induction [109, 125] Enhanced antitumor immunity [126]
Statins Hyperlipemia drug HMGCR Ferroptosis induction [127] Enhanced antitumor immunity [128]
Trigonelline Nutrient additive Nrf2 Ferroptosis induction [129] Unknown  
Artesunate Antimalarial drug ROS Ferroptosis/necroptosis induction [75] Enhanced antitumor immunity [130,131,132]
Shikonin Thrombocytopenia drug RIPK1/RIPK3 Necroptosis induction [52] Enhanced antitumor immunity [133]
Resibufogenin Heart failure drug RIPK3, MLKL Necroptosis induction [134] Unknown  
5-FU Anticancer drug TNF-α/RIPK3 Necroptosis induction [135] Enhanced antitumor immunity [136]
Metformin Anti-diabetes drug GSDMD Pyroptosis induction [137] Enhanced antitumor immunity [138]
Anthocyanin Nutrient NLRP3 Pyroptosis induction [139] Enhanced antitumor immunity [140]
DHA Nutrient GSDMD Pyroptosis induction [141] Enhanced antitumor immunity [142]
Paclitaxel Anticancer drug GSDME Pyroptosis induction [109] Enhanced antitumor immunity [143]
Iron Nutrient Ferrous/GSDME Ferroptosis/necroptosis induction [144, 145] Enhanced antitumor immunity [146]
Doxorubicin Anticancer drug GSH/GSDME2 Ferroptosis/pyroptosis induction [147] Enhanced antitumor immunity [148]