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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Targeting immune checkpoints in hematological malignancies

Fig. 3

Negative regulators of T cell immunity other than PD-1 and CTLA-4. Schematic illustrating receptors and their ligands regulating T cell immunity. Multiple immune checkpoint molecules are differentially implicated in the regulation of activated T cells including LAG-3, TIM-3, and TIGIT. Plus and minus signs denote stimulatory and inhibitory signaling respectively. Single-headed and double-headed arrows denote uni-directional and bi-directional signaling respectively. APC, antigen-presenting cell; TCR, T cell receptor; LAG-3, lymphocyte-activation gene 3; CD112R, CD112 receptor; MHC, major histocompatibility complex; FGL1, fibrinogen-like protein 1; DNAM-1, DNAX accessory molecule 1; TIGIT, T cell immunoreceptor with Ig and ITIM domains; TIM-3, T cell immunoglobulin mucin-3

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