Fig. 3
From: Roles of METTL3 in cancer: mechanisms and therapeutic targeting
Molecular mechanisms underlying regulation of METTL3 on target genes in cancers. METTL3 methylates target transcripts, and the resulting m6A marks recruit m6A reader proteins to determine RNA fate. The target genes of METTL3 are in italics, with those involved in the tumor-suppressive function of METTL3 being boxed. CRC, colorectal cancer; BCa, bladder cancer, NSCLC, non-small cell lung cancer; PDAC, pancreatic ductal adenocarcinoma; HCC, hepatocellular carcinoma; GBM, glioblastoma; GC, gastric cancer; AML, acute myeloid leukemia; OM, ocular melanoma; EC, endometrial cancer; TC, thyroid carcinoma