Table 1 m⁶A modification-related factors

Writer

METTL3/METTL14/WTAP/VIRMA/ZC3H13/RBM15

The m⁶A methyltransferase complex for the majority of m⁶A deposition

[10,11,12,13,14]

METTL16

Responsible for m⁶A modification of U6 snRNA, lncRNAs, and introns of pre-mRNAs

[15,16,17]

METTL5

Responsible for m⁶A modification of 18S rRNA

[18, 19]

ZCCHC4

Responsible for m⁶A modification of 28S rRNA

[20,21,22]

Eraser

FTO

Demethylates m⁶A, also has activity towards m⁶A_m and m¹A

[23,24,25]

ALKBH5

Mainly demethylates m⁶A

[9, 26, 27]

Reader

YTHDC1

Alternative splicing and RNA export

[28, 29]

YTHDC2

mRNA degradation and translation initiation

[30, 31]

YTHDF1

Promotes translation

[32, 33]

YTHDF2

Promotes RNA decay

[34, 35]

YTHDF3

Promotes mRNAs translation and degradation

[36, 37]

IGF2BP1/2/3

Promotes mRNA stability and translation

[38]

hnRNPC/hnRNPG

Regulates mRNA structure and alternative splicing

[39, 40]