From: Roles of METTL3 in cancer: mechanisms and therapeutic targeting
Role | Cancer type | Regulator | Targets | Molecular mechanism | Cellular function | Ref. |
---|---|---|---|---|---|---|
Oncogene | Acute myeloid leukemia | Â | MYC, BCL2, PTEN | Promote translation | Differentiation, apoptosis | [73] |
CEBPZ | SP1, SP2 | Promote translation | Cell cycle regulation, differentiation | [74] | ||
Breast cancer | let-7g | HBXIP | Promote translation (?) | Cell proliferation | [63] | |
 | BCL2 | Promote translation | Proliferation, apoptosis | [75] | ||
Liver cancer | Â | SOCS2 | RNA decay by YTHDF2 | Proliferation, migration | [76] | |
 | RDM1 |  | Proliferation | [77] | ||
 | LINC00958 | RNA stabilization | Lipogenesis, proliferation, migration, invasion | [78] | ||
SUMO1 | Snail | RNA stabilization | Metastasis | [79] | ||
 | Snail | promote translation by YTHDF1 | EMT | [80] | ||
miR24-2 | miR-6097, Pim1 | Â | Tumor growth | [59] | ||
 | CTNNB1 | RNA stabilization | Tumor growth | [81] | ||
miR-186 | Wnt/β-catenin |  | Proliferation, migration, invasion | [60] | ||
Glioblastoma | Â | SOX2 | RNA stabilization by ELAVL1 | Dedifferentiation | [82] | |
 | SRSFs | Nonsense-mediated mRNA decay (NMD) by YTHDC1 | Tumor growth and progression | [83] | ||
Bladder cancer | Â | miR-221/222 | miRNA maturation | Proliferation | [84] | |
 | AFF4, RELA, IKBKB, MYC |  | Proliferation, apoptosis | [85] | ||
 | ITGA6 | Promote translation by YTHDF1/3 | Adhesion, migration, invasion | [86] | ||
chemical carcinogenesis | CPCP | Promote translation | Malignant transformation | [87] | ||
 | SETD7, KLF4 | RNA decay by YTHDF2 | Proliferation, metastasis | [88] | ||
Gastric cancer | miR-4429 | SEC62 | RNA stabilization by IGF2BP1 | Proliferation, apoptosis | [62] | |
 | AKT signaling pathway |  | Proliferation, migration, invasion | [89] | ||
CBP/P300-mediated H3K27ac | HDGF | RNA stabilization by IGF2BP3 | Tumor angiogenesis and glycolysis | [58] | ||
 | ZMYM1 | RNA stabilization by ELAVL1 | EMT | [90] | ||
LncRNA ARHGAP5-AS1 | ARHGAP5 mRNA | RNA stabilization | Chemoresistance | [71] | ||
 | MYC target genes |  | Proliferation, migration, invasion | [91] | ||
LINC00470 | PTEN | RNA decay by YTHDF2 | Proliferation, migration, invasion | [72] | ||
Prostate cancer | Â | GLI1 | Â | Proliferation, migration, apoptosis, | [92] | |
 | MYC |  | Proliferation, migration, invasion. | [93] | ||
 | ITGB1 | RNA stabilization | Cell adhesion | [94] | ||
Lung cancer | miR-600 | β-catenin, TAZ, EGFR, DNMT3A |  | Proliferation, metastasis, apoptosis | [61] | |
 | miR-25-3p | miRNA maturation | Brain metastasis | [95] | ||
TGF-β | JUNB | RNA stabilization | EMT | [96] | ||
 | YAP, MALAT1 | promote translation by YTHDF1/3; RNA stabilization by YTHDF3 | Drug resistance and metastasis | [97] | ||
Colorectal cancer | Â | SOX2 | RNA stabilization by IGF2BP2 | Tumorigenesis, metastasis | [98] | |
 | lncRNA RP11 | Nucleus accumulation | Metastasis | [99] | ||
 | miR-1246 | miRNA maturation | Metastasis | [100] | ||
 | HK2, SLC2A1 | RNA stabilization by IGF2BP2/3 | Activation of the glycolysis pathway | [101] | ||
Butyrate | CCNE1 | RNA stabilization | Proliferation | [57] | ||
 | circNSUN2 | Exporting to cytoplasm | Metastasis | [102] | ||
 | CBX8 | RNA stabilization by IGF2BP1 | Stemness | [103] | ||
Pancreatic cancer | NFIC | miR-25-3p | miRNA maturation | Proliferation, metastasis | [56] | |
 |  |  | Proliferation, invasion | [104] | ||
Osteosarcoma | Â | LEF1 | Â | Proliferation, migration, invasion | [105] | |
 | DRG1 | RNA stabilization by ELAVL1 | Proliferation | [106] | ||
 | ATAD2 |  | Proliferation, migration, invasion | [107] | ||
Oral squamous cell carcinoma | Â | MYC | RNA stabilization by YTHDF1 | Proliferation, invasion, migration | [108] | |
Thyroid carcinoma | Â | TCF1 | RNA stabilization by IGF2BP2 | Activating the Wnt pathway, migration | [109] | |
Uveal melanoma | Â | c-Met | Â | Proliferation, migration, invasion | [110] | |
Ovarian cancer | Â | AKT | Â | Proliferation | [111] | |
Head and neck squamous cell carcinoma | Â | LNCAROD | RNA stabilization | Proliferation, mobility | [112] | |
Cutaneous squamous cell carcinoma |  | ΔNp63 |  | Proliferation | [113] | |
Nasopharyngeal carcinoma | Â | ZNF750 | Â | Apoptosis | [114] | |
Tumor suppressor | Renal cell carcinoma | Â | Â | Â | Proliferation, migration, apoptosis, | [115] |
Glioblastoma | Â | ADAM19 | Â | Self-renewal | [116] | |
Endometrial cancer | Â | PHLPP2, mTORC2 | Promote translation by YTHDF1; RNA decay by YTHDF2 | Proliferation | [117] | |
Ocular melanoma | Â | HINT2 | Promote translation by YTHDF1 | Proliferation, apoptosis | [118] | |
Colorectal cancer | Â | p38/ERK pathways | Â | Proliferation, migration, invasion | [119] | |
Bladder cancer | Â | Â | Â | Â | [120] |