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Table 2 Roles of METTL3 as an m6A methyltransferase in human cancers

From: Roles of METTL3 in cancer: mechanisms and therapeutic targeting

Role

Cancer type

Regulator

Targets

Molecular mechanism

Cellular function

Ref.

Oncogene

Acute myeloid leukemia

 

MYC, BCL2, PTEN

Promote translation

Differentiation, apoptosis

[73]

CEBPZ

SP1, SP2

Promote translation

Cell cycle regulation, differentiation

[74]

Breast cancer

let-7g

HBXIP

Promote translation (?)

Cell proliferation

[63]

 

BCL2

Promote translation

Proliferation, apoptosis

[75]

Liver cancer

 

SOCS2

RNA decay by YTHDF2

Proliferation, migration

[76]

 

RDM1

 

Proliferation

[77]

 

LINC00958

RNA stabilization

Lipogenesis, proliferation, migration, invasion

[78]

SUMO1

Snail

RNA stabilization

Metastasis

[79]

 

Snail

promote translation by YTHDF1

EMT

[80]

miR24-2

miR-6097, Pim1

 

Tumor growth

[59]

 

CTNNB1

RNA stabilization

Tumor growth

[81]

miR-186

Wnt/β-catenin

 

Proliferation, migration, invasion

[60]

Glioblastoma

 

SOX2

RNA stabilization by ELAVL1

Dedifferentiation

[82]

 

SRSFs

Nonsense-mediated mRNA decay (NMD) by YTHDC1

Tumor growth and progression

[83]

Bladder cancer

 

miR-221/222

miRNA maturation

Proliferation

[84]

 

AFF4, RELA, IKBKB, MYC

 

Proliferation, apoptosis

[85]

 

ITGA6

Promote translation by YTHDF1/3

Adhesion, migration, invasion

[86]

chemical carcinogenesis

CPCP

Promote translation

Malignant transformation

[87]

 

SETD7, KLF4

RNA decay by YTHDF2

Proliferation, metastasis

[88]

Gastric cancer

miR-4429

SEC62

RNA stabilization by IGF2BP1

Proliferation, apoptosis

[62]

 

AKT signaling pathway

 

Proliferation, migration, invasion

[89]

CBP/P300-mediated H3K27ac

HDGF

RNA stabilization by IGF2BP3

Tumor angiogenesis and glycolysis

[58]

 

ZMYM1

RNA stabilization by ELAVL1

EMT

[90]

LncRNA ARHGAP5-AS1

ARHGAP5 mRNA

RNA stabilization

Chemoresistance

[71]

 

MYC target genes

 

Proliferation, migration, invasion

[91]

LINC00470

PTEN

RNA decay by YTHDF2

Proliferation, migration, invasion

[72]

Prostate cancer

 

GLI1

 

Proliferation, migration, apoptosis,

[92]

 

MYC

 

Proliferation, migration, invasion.

[93]

 

ITGB1

RNA stabilization

Cell adhesion

[94]

Lung cancer

miR-600

β-catenin, TAZ, EGFR, DNMT3A

 

Proliferation, metastasis, apoptosis

[61]

 

miR-25-3p

miRNA maturation

Brain metastasis

[95]

TGF-β

JUNB

RNA stabilization

EMT

[96]

 

YAP, MALAT1

promote translation by YTHDF1/3; RNA stabilization by YTHDF3

Drug resistance and metastasis

[97]

Colorectal cancer

 

SOX2

RNA stabilization by IGF2BP2

Tumorigenesis, metastasis

[98]

 

lncRNA RP11

Nucleus accumulation

Metastasis

[99]

 

miR-1246

miRNA maturation

Metastasis

[100]

 

HK2, SLC2A1

RNA stabilization by IGF2BP2/3

Activation of the glycolysis pathway

[101]

Butyrate

CCNE1

RNA stabilization

Proliferation

[57]

 

circNSUN2

Exporting to cytoplasm

Metastasis

[102]

 

CBX8

RNA stabilization by IGF2BP1

Stemness

[103]

Pancreatic cancer

NFIC

miR-25-3p

miRNA maturation

Proliferation, metastasis

[56]

   

Proliferation, invasion

[104]

Osteosarcoma

 

LEF1

 

Proliferation, migration, invasion

[105]

 

DRG1

RNA stabilization by ELAVL1

Proliferation

[106]

 

ATAD2

 

Proliferation, migration, invasion

[107]

Oral squamous cell carcinoma

 

MYC

RNA stabilization by YTHDF1

Proliferation, invasion, migration

[108]

Thyroid carcinoma

 

TCF1

RNA stabilization by IGF2BP2

Activating the Wnt pathway, migration

[109]

Uveal melanoma

 

c-Met

 

Proliferation, migration, invasion

[110]

Ovarian cancer

 

AKT

 

Proliferation

[111]

Head and neck squamous cell carcinoma

 

LNCAROD

RNA stabilization

Proliferation, mobility

[112]

Cutaneous squamous cell carcinoma

 

ΔNp63

 

Proliferation

[113]

Nasopharyngeal carcinoma

 

ZNF750

 

Apoptosis

[114]

Tumor suppressor

Renal cell carcinoma

   

Proliferation, migration, apoptosis,

[115]

Glioblastoma

 

ADAM19

 

Self-renewal

[116]

Endometrial cancer

 

PHLPP2, mTORC2

Promote translation by YTHDF1; RNA decay by YTHDF2

Proliferation

[117]

Ocular melanoma

 

HINT2

Promote translation by YTHDF1

Proliferation, apoptosis

[118]

Colorectal cancer

 

p38/ERK pathways

 

Proliferation, migration, invasion

[119]

Bladder cancer

    

[120]