Fig. 2
From: tRNA-derived RNA fragments in cancer: current status and future perspectives
Biological functions of tRFs. (A) RNA splicing. tRFs can affect RNA splicing by targeting the 3′-UTR regions of mRNAs or competitive binding of target mRNAs. (B) Translation regulation. YB-1 binding tRFs repress global translation by displacing translation eukaryotic initiation factor and induce assembly of SGs. tRFs can also regulate translation by interacting with ribosomes. (C) Epigenetic regulation. tRFs can inhibit LTR-retrotransposons or participate in non-coding RNA regulation