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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: tRNA-derived RNA fragments in cancer: current status and future perspectives

Fig. 4

Mechanisms of action of tRFs in breast cancer. Hypoxia-induced tRNAGlu, tRNAAsp, tRNAGly, and tRNATyr can interact with YBX1 and suppress breast cancer metastasis. Hypoxia-induced tDR-0009 and tDR-7336 can facilitate the doxorubicin resistance in triple-negative breast cancer cells. tRF3E can inhibit cell proliferation by binding with NCL. 5′-tiRNAVal inhibits breast cancer progression by directly targeting FZD3 3′-UTR sequence. RUNX1-regulated tRFs and sex hormone-dependent tiRNA (SHOT-RNAs) are associated with cell proliferation

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