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Fig 2 | Journal of Hematology & Oncology

Fig 2

From: Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma

Fig 2

Various factors could cause DNA single-strand breaks (SSBs). SSBs are repaired by poly (ADP-ribose) polymerase (PARP) through the base excision repair (BER) mechanism. Therefore, the application of PARP inhibitors will enable BER and cause many SSBs. These lesions will transfer to DNA double-strand breaks (DSBs) during cell proliferation. DSBs are repaired by BRCA through the gene conversion (GC) pathway in normal cells. However, in BRCA-loss cancer cells, DSBs cannot be repaired and will lead to fatal genomic instability

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