From: A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target
Gene | Genetic alteration | Disease | Effect/prognostic value | Reference |
---|---|---|---|---|
Hematological tumors | ||||
 WEE1 | Over-expression | ALL; AML; MM; CML; CLL; DLBCL | Crucial for cell viability of cancer cells (experimentally proven). | |
Copy number Gain | AML | Biological effect or prognostic value unknown | [55] | |
 PKMYT1 | Over-expression | ALL; MM | Crucial for cell viability of cancer cells (experimentally proven). | |
Solid tumors | ||||
 WEE1 | Over-expression | GC; MaM; GL; OC; CC | Associated with lymph node involvement, induction of metastasis, increased biomarkers of proliferation (CCND1, Ki67 or CCNA1), resistance to treatment and poor overall survival. | |
Mutation | PA | Insertion causing decrease WEE1 expression upon DNA damage | [33] | |
 PKMYT1 | Over-expression | HC; CC; GLB; NSCLC; N; GS | Associated with tumor progression, aggressive disease and poor overall survival. | |
Mutation | N | Biological effect or prognostic value unknown | [61] |