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Table 2 Effects of standard of care chemo/radiotherapy agents on cell cycle checkpoints activation

From: A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target

Chemotherapy agents/radiotherapy Intra S checkpoint G2/M checkpoint WEE1 and/or PKMYT1 experimentally proven involvement in cancer model
Actinomycin No Yes [70, 71] WEE1 upregulation [71]
Azacitidine No Yes [72] NA
Bleomycin No Yes [73] NA
Carboplatin No Yes [74] NA
Cisplatin No Yes [75, 76] WEE1 inhibition enhanced cytotoxicity [76, 77]
Cyclophosphamide NA NA WEE1 upregulation [78]
Cytarabine Yes [79, 80] Yes [79, 80] WEE1 upregulation [38, 81]
Clofarabine Yes [35] No WEE1 inhibition enhanced cytotoxicity [35]
Daunorubicin Yes [82] Yes [82] NA
Decitabine No Yes [83] NA
Docetaxel No Yes [84, 85] NA
Doxorubicin No Yes [86] WEE1 upregulation [86]; WEE1 inhibition enhanced cytotoxicity [35]
Epirubicin No Yes [87, 88] WEE1 inhibition enhanced cytotoxicity [89]
Epothilone No Yes [90] NA
Etoposide No Yes [91] WEE1 inhibition enhanced cytotoxicity [67]
Fluorouracil Yes [92] No WEE1 inhibition enhanced cytotoxicity [92]
Fludarabine Yes [80] No NA
Gemcitabine Yes [80] No WEE1 upregulation [93]; WEE1 inhibition enhanced cytotoxicity [94]
Hydroxyurea Yes [95] No WEE1 inhibition enhanced cytotoxicity [96]
Idarubicin No Yes [97] NA
Irinotecan No Yes [98] WEE1 inhibition enhanced cytotoxicity [99]
Mechlorethamine Yes [100] Yes [100] NA
Mercaptopurine Yes [101] No NA
Methotrexate Yes [102] No WEE1 inhibition enhanced cytotoxicity [103]
Mitoxantrone No Yes [104] WEE1 inhibition enhanced cytotoxicity [78]
Oxaliplatin No Yes [105] WEE1 inhibition enhanced cytotoxicity [106]
Paclitaxel No Yes [107] WEE1 inhibition enhanced cytotoxicity [108]
Pemetrexed Yes [109] No WEE1 inhibition enhanced cytotoxicity [110]
Radiotherapy (ionizing radiation) No Yes [111] WEE1 inhibition enhanced cytotoxicity [68]
Teniposide Yes [112] Yes [112] NA
Thioguanine Yes [113] Yes [113] WEE1 inhibition enhanced cytotoxicity [65]
Topotecan No Yes [114] WEE1 inhibition enhanced cytotoxicity [115]
Vinblastine No Yes [116] NA
Vincristine No Yes [117] WEE1 inhibition enhanced cytotoxicity [118]