Table 2 Effects of standard of care chemo/radiotherapy agents on cell cycle checkpoints activation
From: A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target
Chemotherapy agents/radiotherapy | Intra S checkpoint | G2/M checkpoint | WEE1 and/or PKMYT1 experimentally proven involvement in cancer model |
|---|---|---|---|
Actinomycin | No | WEE1 upregulation [71] | |
Azacitidine | No | Yes [72] | NA |
Bleomycin | No | Yes [73] | NA |
Carboplatin | No | Yes [74] | NA |
Cisplatin | No | ||
Cyclophosphamide | NA | NA | WEE1 upregulation [78] |
Cytarabine | |||
Clofarabine | Yes [35] | No | WEE1 inhibition enhanced cytotoxicity [35] |
Daunorubicin | Yes [82] | Yes [82] | NA |
Decitabine | No | Yes [83] | NA |
Docetaxel | No | NA | |
Doxorubicin | No | Yes [86] | WEE1 upregulation [86]; WEE1 inhibition enhanced cytotoxicity [35] |
Epirubicin | No | WEE1 inhibition enhanced cytotoxicity [89] | |
Epothilone | No | Yes [90] | NA |
Etoposide | No | Yes [91] | WEE1 inhibition enhanced cytotoxicity [67] |
Fluorouracil | Yes [92] | No | WEE1 inhibition enhanced cytotoxicity [92] |
Fludarabine | Yes [80] | No | NA |
Gemcitabine | Yes [80] | No | WEE1 upregulation [93]; WEE1 inhibition enhanced cytotoxicity [94] |
Hydroxyurea | Yes [95] | No | WEE1 inhibition enhanced cytotoxicity [96] |
Idarubicin | No | Yes [97] | NA |
Irinotecan | No | Yes [98] | WEE1 inhibition enhanced cytotoxicity [99] |
Mechlorethamine | Yes [100] | Yes [100] | NA |
Mercaptopurine | Yes [101] | No | NA |
Methotrexate | Yes [102] | No | WEE1 inhibition enhanced cytotoxicity [103] |
Mitoxantrone | No | Yes [104] | WEE1 inhibition enhanced cytotoxicity [78] |
Oxaliplatin | No | Yes [105] | WEE1 inhibition enhanced cytotoxicity [106] |
Paclitaxel | No | Yes [107] | WEE1 inhibition enhanced cytotoxicity [108] |
Pemetrexed | Yes [109] | No | WEE1 inhibition enhanced cytotoxicity [110] |
Radiotherapy (ionizing radiation) | No | Yes [111] | WEE1 inhibition enhanced cytotoxicity [68] |
Teniposide | Yes [112] | Yes [112] | NA |
Thioguanine | Yes [113] | Yes [113] | WEE1 inhibition enhanced cytotoxicity [65] |
Topotecan | No | Yes [114] | WEE1 inhibition enhanced cytotoxicity [115] |
Vinblastine | No | Yes [116] | NA |
Vincristine | No | Yes [117] | WEE1 inhibition enhanced cytotoxicity [118] |