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Table 4 Differences in ArcherDX and CAPP-seq

From: Advances in the assessment of minimal residual disease in mantle cell lymphoma

  ArcherDX CAPP-seq
Strengths -Low input
-Anchored multiplex PCR
-High sensitivity
-Good for low allelic mutations
-Fast turnaround time
-Easy workflow
-Uses hybridization capture method
-Can survey multiple loci at once
-Cost effective
Weaknesses -Not able to survey multiple loci -Need large input
-Prior knowledge of tumor’s genetic landscape
-Requires tumor-specific selector
-Sample cross contamination
-Allelic bias in capture reagent