Table 4 Differences in ArcherDX and CAPP-seq

Strengths

-Low input

-Anchored multiplex PCR

-High sensitivity

-Good for low allelic mutations

-Fast turnaround time

-Easy workflow

-Uses hybridization capture method

-Can survey multiple loci at once

-Cost effective

Weaknesses

-Not able to survey multiple loci

-Need large input

-Prior knowledge of tumor’s genetic landscape

-Requires tumor-specific selector

-Sample cross contamination

-Allelic bias in capture reagent