Fig. 1

BCMA gene and protein. BCMA is encoded by the TNFRSF17 gene (BCMA gene) located on the short arm of chromosome 16 (16p13.13). The BCMA gene comprised of 3 exons separated by 2 introns. BCMA is a type III transmembrane glycoprotein, with an extracellular N terminus containing a conserved motif of 6 cysteines and an intracellular tumor necrosis factor receptor-associated factor (TRAF) binding domain that triggers the activation of nuclear factor κ-light-chain enhancer of activated B cells (NF-κβ) signaling