Fig. 1

Association of HDL cholesterol and apolipoprotein A1 levels with risk of any cancer in individuals from the Copenhagen General Population Study. Hazard ratios and 95% confidence intervals (CIs) were obtained from Cox proportional hazards regression with restricted cubic splines. Multivariable adjustment included age, sex, body mass index, smoking status, cumulative tobacco consumption, alcohol intake, leisure-time physical activity, education, income, plasma triglycerides, lipid-lowering therapy, C-reactive protein, and baseline chronic disease (ischemic heart disease, chronic obstructive pulmonary disease, and diabetes). The median values of HDL cholesterol and apolipoprotein A1 were chosen as reference. The red line represents the hazard ratio and the dotted lines 95% CIs. Areas of light blue and purple represent the distribution of levels of HDL cholesterol and apolipoprotein A1, respectively. HDL=high-density lipoprotein