Fig. 2

Association of HDL cholesterol and apolipoprotein A1 levels with risk of any cancer and nine major cancer forms in individuals from the Copenhagen General Population Study. Hazard ratios and 95% confidence intervals (CIs) were obtained from Cox proportional hazards regression multivariable adjusted for age, sex, body mass index, smoking status, cumulative tobacco consumption, alcohol intake, leisure-time physical activity, education, income, plasma triglycerides, lipid-lowering therapy, C-reactive protein, and baseline chronic disease (ischemic heart disease, chronic obstructive pulmonary disease, and diabetes). P for trend was obtained from Wald’s test. Numbers vary slightly due to exclusion of individuals with baseline cancer relevant for the specific cancer form. The sum of the nine major cancer forms exceeds the number of any cancer, as some individuals developed more than one specific cancer form. Hematological cancer included: non-Hodgkin lymphoma, Hodgkin’s lymphoma, multiple myeloma, leukemia, and myeloproliferative neoplasm. Respiratory cancer included: larynx and lung. Gynecological cancer included: cervix uteri, corpus uteri, and ovaries. Urological cancer included: kidney, bladder, and excretory urinary tract. Gastrointestinal cancer included: oral cavity and pharynx, esophagus, stomach, colon/rectum/anus, liver and biliary tract, and pancreas. HDL=high-density lipoprotein