Fig. 3

Tumor response to different antitumor strategies. The failure of conventional therapies is due to the tumor and the CSC mechanisms to initiate the carcinogenesis process. For this reason, the new therapies focus on TME, including the CSC secretome. However, CSCs use different pathways to fulfill their functions; therefore, targeting only one of the pathways can lead to tumor relapse. The new therapies are aimed at simultaneously blocking several pathways for better outcomes