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Table 1 Timeline of events from initial COVID-19 diagnosis to second COVID-19 episode

From: Severe COVID-19 virus reactivation following treatment for B cell acute lymphoblastic leukemia

Date

4/8/20

4/25/20

5/7/20

5/11/20

5/14/20

6/8/20

6/18/20

6/25/20

6/28/20

SARS-CoV-2 PCR

Positive

Positive

Negative

Negative

  

Positive

 

Positive

COVID-19 antibodies

 

Positive (1:80)

  

Positive (1:960)

  

Negative

 

COVID-19 symptoms

 

Fever, cough, abdominal pain, nausea, vomiting

No oxygen requirement

      

Fever, acute respiratory distress requiring high-flow nasal cannula

White blood cell count (× 103/uL)

3.5

11.7

5.0

  

10.6

3.5

0.3

4.6

Absolute lymphocyte count (× 103/uL)

1.9

1.4

1.6

  

2.6

0.2

0.1

0.1

C-reactive protein (mg/L)

 

168.1

9.2

     

314.3

Erythrocyte sedimentation rate (mm/h)

        

 > 145

Ferritin (ng/mL)

 

4569

3662

     

 > 33,511

Interleukin 6 (pg/mL)

 

93.4

      

139.0

Fibrinogen (mg/dL)

 

603

567

     

710

D-dimer (μg/mL FEU)

 

0.83

0.39

     

3.54

CT chest findings

 

Moderate, bilateral, scattered ground-glass opacities

      

Extensive, diffuse ground-glass opacities including previously unaffected sites

Leukemia treatment

     

Rituximab

Cytarabine

Dasatinib