Skip to main content
Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: High-throughput approaches for precision medicine in high-grade serous ovarian cancer

Fig. 3

Current targeted therapies for high-grade serous ovarian cancer. a Anti-angiogenic agents. Cancer cells secrete vascular endothelial growth factor (VEGF) A that binds to vascular endothelial growth factor receptor (VEGFR) to promote angiogenesis and proliferation. Bevacizumab is a monoclonal antibody which inhibits the binding of VEGF to VEGFR, thus hindering angiogenesis and tumor growth. b Poly(ADP-ribose) polymerase (PARP) inhibitors. PARP enzymes mediate base excision repair of DNA single-strand breaks. Inhibition of PARP results in the accumulation of single-strand breaks culminating in DNA double-strand breaks. In cells with homologous repair deficiencies, double-strand breaks are not repaired resulting in replication fork collapse, chromosome instability and cell death. BER base excision repair, PARP poly (ADP-ribose) polymerase, VEGF vascular endothelial growth factor, VEGFR vascular endothelial growth factor receptor

Back to article page