Table 1 EBMT criteria for SOS/VOD in adults and children

Classical (first 21 days after HSCT)

Bilirubin ≥ 2 mg/dL and 2 of the following criteria must be present:

• Painful hepatomegaly

• Weight gain > 5%

• Ascites

Late onset (> 21 days after HSCT)

Classical VOD/SOS beyond day 21

OR

Histologically proven SOS/VOD

OR

 ≥ 2 of the following criteria must be present:

• Bilirubin ≥ 2 mg/dL (or 34 μmol/L)

• Painful hepatomegaly

• Weight gain > 5%

• Ascites

AND hemodynamical and/or ultrasound evidence of SOS/VOD

No limitation for time of onset of SOS/VOD

The presence of ≥ 2 of the following:^a

• Unexplained consumptive and transfusion-refractory thrombocytopenia^b

• Otherwise unexplained weight gain on 3 consecutive days despite the use of diuretics or a weight gain > 5% above baseline value

• Hepatomegaly^c (best if confirmed by imaging) above baseline value

• Ascites^c (best if confirmed by imaging) above baseline value

• Rising bilirubin from a baseline value on 3 consecutive days or bilirubin ≥ 2 mg/dL within 72 h