Fig. 4
From: Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma
NQO1 and GSTP1 regulate cancer cell proliferation and oxidative stress. a Cell proliferation rates were determined by MTT assay. U87MG/EGFRvIII cells were transfected with siRNAs for depleting NQO1, GSTP1 or both. The cell proliferation was determined at different time points (upper). U87MG/EGFRvIII cells were transfected with various constructs for overexpressing NQO1, GSTP1 or both. The cell proliferation was determined at different time points (lower). The effect of knockdown and overexpression NQO1 and GSTP1 in the U87MG/EGFRvIII cells. b ROS levels, c LDH levels, d Carbonyl expression levels and e GSH/GSSG ratios. Data are means ± SEM (*p < 0.05; **p < 0.01; ***p < 0.001, n = 3)